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Observe Intently (1)modafinil will increase the stage or effect of citalopram by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Observe. Citalopram 20 mg/day is the most suggested dose for clients having CYP2C19 inhibitors due to danger of QT prolongation.Abuse Likely: In scientific trials, modafinil use generates euphoric and psychoact